fruit Fibromyalgia


Chronic Fatigue

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Chronic Fatigue and CFS

Chronic ill health is a "normal condition" among adult North Americans. Aching and fatigue are the two most common complaints. Close to 50% of the adult population in the US and Canada report chronic symptoms such as headache, fatigue, joint and muscle pain.

Data from the U.S. National Ambulatory Medical Care Survey (NAMCS) estimated that the number of outpatient visits for fatigue was 7 million visits; 9.6 million visits for headaches; 17 million visits for joint pains; 14 million visits for skin rash; and 7 million visits for depression. Patients commonly report experiencing multiple symptoms. Studies have shown that when patients complete symptom checklists one third of patients complain of 0-1 symptoms, one-third complain of 2-3 symptoms, and one-third complain of 4 or more symptoms.

Many of theses patients who are not well but do not have the markers of specific disease. Patients with in-between disease have some of the symptoms and signs that suggest the diagnosis of specific disease but not everything fits together. In primary medical practice non-specific and in-between disease are more common than the nicely packaged diseases described in textbooks.

A patient may suffer fatigue and joint pains, for example, but not show rheumatoid factor or have X-Ray signs of rheumatoid arthritis; she feels like a second-class citizen since she does not have a definitive diagnosis. Physicians have been tempted in the past to dismiss these patients as hypochondriacs, attribute their symptoms to "stress" or try to include them in diagnoses such as depression. Some MDs still believe in psychosomatic illness and will frustrate suffering patients who get no help from them.

Chronic Fatigue Syndrome (CFS), fibromyalgia and related disorders are not discrete diseases in the usual sense, but patterns of maladaptive responses to food and the environment. We believe that chronic fatigue syndrome and fibromyalgia are symptom complexes and are often caused by delayed pattern food allergy. Both conditions tend to co-exist and both are part of a larger illness complex. The general classification is non-specific hypersensitivity disease.

Chronic fatigue and fibromyalgia and should be treated with diet revision as the first and most essential form of therapy. Long-term and precise management of food intake is required to sustain improvements.

CFS is characterized by persistent and debilitating fatigue and additional symptoms such as sore throat, headache, tender muscles, aching, stiffness, joint pains, difficulty concentrating, thinking and loss of short-term memory. Fatigue and aching are often associated so that the diagnoses of CFS and Fibromyalgia overlap - both descriptions point to similar clusters of symptoms. Occasionally, one symptom will dominate - some people remain energetic but are stopped by pain, for example and should be diagnosed as ‘fibromyalgia”; others are disabled by fatigue but have no pain. Most people we see have both symptoms and the diagnosis of Fibromyalgia and chronic fatigue can be made together.

The symptoms of chronic fatigue and fibromyalgia are mostly likely produced by the combined action of many chemicals in food and released by immune cells that are activated by food proteins that act as triggers to immune cells. Immune cell chemicals are referred to as cytokines and are potent. A few micrograms of a cytokine circulating in the blood can feel awful - "it feels like a truck ran over me." Attempts to change the chemistry of the brain with prescription drugs, herbs, magnets, acupuncture, vitamins, minerals, green goop and a host of other odd concoctions are generally futile and may make matters worse.

Viral hepatitis may simmer for many years causing chronic fatigue. Similar nonspecific symptoms occur in the early stages of the other diseases such as rheumatoid arthritis, lupus erythematosis and multiple sclerosis. These are hypersensitivity diseases, driven by immune activity, which probably involve food and airborne materials that excite immune responses. A thoughtful, broad approach to environmental determinants is required. Food allergy and other food supply problems are usually not considered. Toxicity from industrial and domestic sources is also seldom considered. We recommend complete, thorough diet revision as a prerequisite of investigating and treating the problem.

Diabetes 2 is a collection of well-concealed disease processes that involve problems in the foods themselves, abnormal responses to foods, compulsive eating with an excessively high caloric intake, a sedentary life style and weight gain. You could argue that diabetes 2 is too much food disease or that diabetes 2 is sitting too much disease.  Diabetes 2 is a process that usually goes undetected for many years. Early symptoms are the most common symptoms that people suffer such as fatigue, irritability and difficulty concentrating.  With rising blood sugar levels, increased thirst leads to increased water intake and increased urination. The first stage of Diabetes 2 is referred to as "glucose intolerance" since blood glucose levels rises excessively after eating food. Fasting blood sugars remain normal and other signs of diabetes have not yet appeared. As the glucose intolerance progresses, high glucose levels become more persistent and other problems appear.  Fatigue is a dominant symptom.

The Food Allergy Complex

Fatigue, sleepiness, mood, and sleep-disturbances are consistent symptoms of the delayed pattern food allergy complex. The clinical correlation of more specific food-allergic symptoms (nose congestion, headache, and abdominal pain) with fatigue and insomnia is so consistent that food allergic symptoms which do not include a disturbance of the arousal system should be considered unusual.

The type III food allergy pattern is delayed hypersensitivity presenting as a whole-body systemic response involving several organ systems - a chronic illness with features of a recurrent flu-like syndrome. Gastrointestinal tract dysfunction seems to be central to the pathogenesis of a variety of systemic manifestations. The most common, milder manifestations involve the Irritable Bowel as the center of the type III pattern and other diagnoses cluster around the central gastrointestinal tract dysfunction - migraine, Fibromyalgia, fatigue, depression, chronic rhinitis, sinusitis, asthma, and arthralgias are typical associations.

Knicker stated: "Delayed adverse reactions to foods are exceedingly varied, and may involve virtually any organ system. Some reactions are classically allergic and at times may reflect delayed IgE-mediated mechanisms. Others involve a single organ system, or multiple organ systems (e.g. the central nervous system, respiratory system, skin, musculoskeletal apparatus, gastrointestinal system, cardiovascular system etc.) with puzzling combination of symptoms."

Mechanisms in delayed patterns of food allergy are:

  • the neuro-immunologic responses of the gastrointestinal tract with local symptoms and broadcast of peptides and cytokines which produce systemic symptoms
  • increased gastrointestinal tract permeability and the abnormal entry of food antigens and/or immune complexes into the circulation
  • the formation of circulating immune complexes
  • complement activation usually by immune complexes
  • the action of chemical mediators released by activated mucosal, circulating, and tissue-bound immune cells
  • the activation of cell-mediated immunity involving mast cells, eosinophils macrophages, lymphocytes and a host of cytokines.

Since this category of disease is based on a complex of pathophysiological mechanisms, it contains a surprisingly large spectrum of disease. Consider three categories of disorders:

  1. Common recognized syndromes
  2. Specific diseases
  3. Nonspecific illness

Syndromes such as irritable bowel syndrome, migraine, panic disorder, depression, chronic fatigue, fibrositis or fibromyalgia can be collected under the title of type III pattern. All the rheumatic diseases, autoimmune diseases, multiple sclerosis, type 1 diabetes, thyroiditis, Crohn's disease, psoriasis are hypersensitivity diseases that can be included along with common specific problems that are related to classical allergy - asthma, atopic dermatitis, urticaria, anaphylaxis, angioedema, allergic gastroenteropathy, and allergic arthritis.

Many of the ever-enlarging pool of patients who are not well but who do not have the markers of specific can be included. Patients with in-between disease have some of the symptoms and signs that suggest the diagnosis of specific disease but not everything fits together. Most chronic diseases take many years to evolve so that many in-between patients are on their way to the final disease product.

The concept of delayed patterns of immune response ("food allergy") to food materials provides both a theoretic and practical basis for interpreting symptoms of patients with both specific diseases and non-specific syndromes. The presence of food allergy (as a pathophysiological mechanism) is concealed in a variety of nosological diagnoses such as migraine headaches, asthma, eczema, irritable bowel syndrome, depression, panic disorder, and arthritis. These syndromes tend to cluster in type III patients. Learn More About Type 3 pattern Food Allergy.

The Alpha Nutrition Program

The Alpha Nutrition Program is designed to improve aching, chronic fatigue and related disorders. The most definitive clearing program is a food holiday, using an elemental nutrient formula (Alpha ENF), composed of nutrients in their pure form with no other food intake. Alpha ENF allows a sick person to return to a baseline of normal functioning, without the intake of numerous adverse substances that may have been present in their food supply.


  • The Fibromyalgia - Chronic Fatigue Center is devoted to explaining a complicated subject. We offer rich resources online and encourage our readers to further pursue their interest by reading our books. This is an educational resource and order portal developed by Environmed Research Inc. Alpha Education books refer to the Alpha Nutrition Program a standard method of diet revision.

    Managing Aching and Fatigue by Stephen Gislason MD is a book about non specific illnesses with aching and fatigue as prominent symptoms. Diagnoses such as Chronic Fatigue Syndrome, Fibromyalgia, Depression, Irritable Bowel have become popular. Some patients say " I feel sick all over". These are overlapping symptom complexes and are often part of a larger illness complex. Dr. Gislason explains explains how food allergy causes many diseases that can be corrected by using proper diet revision. Proper, complete diet revision is the first and most essential form of therapy. Long term management of food intake and exercise are required to sustain improvements. Drug prescriptions are best avoided. You are encouraged to learn all you can about delayed pattern food allergy. You will need to understand the proper strategy of diet revision using the Alpha Nutrition Program. May may consider starting your recovery by going on a Food Holiday.

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    The book Aching and Fatigue is used with the Alpha Nutrition Program.
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    Immunology Notes
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