Hyperactivity (ADHD) Citations and Abstracts

Whenever children are sick or influenced by food and/or airborne chemicals, their brain function is compromised and symptoms include disturbances of sensing, feeling, remembering and acting. Their learning is impaired and their behavior may be disturbed. The intention of compassionate biological management is to restore orderly, normal functioning of the child by careful environmental and food input control. There are different types of food allergy. The immediate or type 1 food allergy pattern is easily recognized because it involves quick and   dramatic symptoms. Delayed patterns of food allergy are not so obvious and generally go unrecognized. Allergy skin tests do not show this problem nor do IGE antibody tests such as RAST or ELIZA.  Delayed patterns of food allergy are responsible for causing common but ill-defined illness patterns in children.

Course Work Some Selected References:

Bobner, RF. Marchionda LM, Benz CR. et al. Behavioral Disorders A Nutrition Checklist. Academic Therapy. 1982 17:4 457-484.

Egger J. Psychoneurological aspects of food allergy. Europ. Jour. Clin. Nutrition 1991:45(suppl 1);35-45.

Feingold BF. Hyperkinesis and learning disabilities linked to artificial food flavours and colours. Am Jour Nursing 1979;75:797

National Institute of Health, Concensus, Development Conference Draft Statement. Defined diets and childhood hyperactivity. Washington DC: NIH, 1982.

Behar D et al. Sugar challenge testing with children considered behaviorally "sugar reactive". Nutrition and Behavior 1984;1:277-288.

Glick Z, Oku J, Bray G. Effects of polyphenols on food intake and body weight of lean and obese rats. Nutrition and Behavior 1982;1:75-78.

Gardner R. Aromatic heterocyclic compounds as principal inciters of allergic responses. Soc Clin Ecol:14th Seminar Ed.

Margolin D. Hyperkinetic child syndrome and brain monoamines: pharmacology and therapeutic implications. Journ. of Clin. Psych. 1978;12-130.

Weiss G. Followup studies on outcome of hyperactive children. Psychopharm Bul. 1985;21(2):169-177.

Hechtman L. Adolescent outcome of hyperactive children treated with stimulants in childhood: a review. Psychopharm Bul. 1985;21(2):178-191.]

Egger J. The Hyperkinetic Syndrome. In Food Allergy. Brostoff and Challacombe eds. 1987; 674-687. Bailliere Tindell.

Egger AU et al. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet 1985;8428(I):540-545.

Egger J Psychoneurological aspects of food allergy. Eur J Clin Nutr, 1991, 45 Suppl 1:, 35-45

Abstracts

Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome.

Author

Egger J; Carter CM; Graham PJ; Gumley D; Soothill JF

Source

Lancet, 1985 Mar 9, 1:8428, 540-5

Abstract

76 selected overactive children were treated with an oligoantigenic diet, 62 improved, and a normal range of behaviour was achieved in 21 of these. Other symptoms, such as headaches, abdominal pain, and fits, also often improved. 28 of the children who improved completed a double-blind, crossover, placebo-controlled trial in which foods thought to provoke symptoms were reintroduced. Symptoms returned or were exacerbated much more often when patients were on active material than on placebo. 48 foods were incriminated. Artificial colorants and preservatives were the commonest provoking substances, but no child was sensitive to these alone.

 

Oligoantigenic diet treatment of children with epilepsy and migraine

Author

Egger J; Carter CM; Soothill JF; Wilson J

Address

Department of Neurology, Hospital for Sick Children, London.

Source

J Pediatr, 1989 Jan, 114:1, 51-8

Abstract

We studied the role of oligoantigenic diets in 63 children with epilepsy; 45 children had epilepsy with migraine, hyperkinetic behavior, or both, and 18 had epilepsy alone. Of the 45 children who had epilepsy with recurrent headaches, abdominal symptoms, or hyperkinetic behavior, 25 ceased to have seizures and 11 had fewer seizures during diet therapy. Headaches, abdominal pains, and hyperkinetic behavior ceased in all those whose seizures ceased, and in some of those whose seizures did not cease. Foods provoking symptoms were identified by systematic reintroduction of foods, one by one; symptoms recurred with 42 foods, and seizures recurred with 31; most children reacted to several foods. Of 24 children with generalized epilepsy, 18 recovered or improved (including 4 of 7 with myoclonic seizures and all with petit mal), as did 18 of 21 children with partial epilepsy. In double-blind, placebo-controlled provocation studies, symptoms recurred in 15 of 16 children, including seizures in eight; none recurred when placebo was given. Eighteen other children, who had epilepsy alone, were similarly treated with an oligoantigenic diet; none improved.

 

Topographic mapping of brain electrical activity in children with food-induced attention deficit hyperkinetic disorder.

Author

Uhlig T; Merkenschlager A; Brandmaier R; Egger J

Address

Institute for Child Health Research, Clinical Sciences Division, West Perth, Australia.

Source

Eur J Pediatr, 1997 Jul, 156:7, 557-61

Abstract

In 15 children suffering from food induced attention deficit hyperkinetic syndrome, topographic EEG mapping of brain electrical activity was carried out following avoidance and ingestion of previously identified provoking foods. A crossover design was used and recordings were interpreted independently by two investigators, one of whom was blind to the order of testing. During consumption of provoking foods there was a significant increase in betal activity in the frontotemporal areas of the brain. This investigation is the first one to show an association between brain electrical activity and intake of provoking foods in children with food-induced attention deficit hyperactivity disorder. CONCLUSIONS: These data support the hypothesis that in a subgroup of children with attention deficit hyperactivity disorder certain foods may not only influence clinical symptoms but may also alter brain electrical activity.

 

Effect of diet treatment on enuresis in children with migraine or hyperkinetic behavior.

Author

Egger J; Carter CH; Soothill JF; Wilson J

Address

Hospital for Sick Children, London, England.

Source

Clin Pediatr (Phila), 1992 May, 31:5, 302-7

Abstract

Twenty-one children with migraine and/or hyperkinetic behavior disorder which was successfully treated with an oligoantigenic (few-foods) diet also suffered from nocturnal and/or diurnal enuresis. On diet, the enuresis stopped in 12 of these children and improved in an additional four. Identification of provoking foods was by sequential reintroduction of the foods that were avoided on the oligoantigenic diet. In eight of the 12 children who recovered on the oligoantigenic diet and in the four who improved, reintroduction of one or more foods provoked a reproducible relapse of the enuresis. Nine children were subjected to a placebo-controlled, double-blind reintroduction of provoking foods. Six children relapsed during testing with incriminated foods; none reacted to placebo. Enuresis in food-induced migraine and/or behavior disorder seems to respond, in some patients, to avoidance of provoking foods.

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