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Topics from the book, The Human Brain by Stephen Gislason MD

Brain Drug Issues & Warnings

Some Topics from the book

Tuning into the Universe
Connected to the Environment
How Many Senses?
Misunderstanding Mind/Body
Mental Illness?
Right & Left Brain
Neurons
History of Mind Drugs
Prescription Drug Abuse
Psychiatry versus Biology
Schizophrenia
Psychosomatic
Mechanisms of Brain Dysfunction
Nutrition & Brain
Allergy and the Brain
Wheat Gluten and the Brain
Attention Deficits
Depression
Is Stress Real ?
Preventing Strokes
Memory
Self Regulation
Intelligence
Thinking
Is Stress Real?
Catecholamines
Dopamine
Amino Acids
Serotonin

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Gluten and the Brain

Celiac disease is the best studied form of delayed pattern food allergy caused by eating wheat and other cereal grains. A surprising range of disease is triggered by the proteins in these foods, collectively referred to as "gluten". Celiac disease may present as a vague illness, even a mental illness.

Patients often complain of  dysphoria with fatigue, difficulty in concentration, loss of recent memory, irritability, loss of pleasure and interests, often with sleep disturbances. Sleep and dreaming are influenced by food problems. Most people eat their major meal in the evening and snack at night. This food is digested and absorbed during the night and symptoms often emerge as you sleep. Some allergenic effects tend to peak at night - asthma, migraine, body pains, and itching are often at their worst. Sleep disturbances include difficulty falling asleep, frequent waking and nightmares. 

Gluten and Cerebellar Ataxia

One example of specific brain injury from eating gluten is cerebellar ataxia. The cerebellum looks after the coordination and smoothing of movements so that problems here show up as movement disorders. Gluten sensitivity, with or without classical celiac disease symptoms and intestinal pathology, is a treatable cause of cerebellar ataxia. Bushara et al reported: We investigated the prevalence of abnormally high serum immunoglobulin A (IgA) and IgG anti-gliadin antibody titers and typical human lymphocyte antigen (HLA) genotypes in 50 patients presenting with cerebellar ataxia who were tested for molecularly characterized hereditary ataxias. A high prevalence of gluten sensitivity was found in patients with sporadic (7/26; 27%) and autosomal dominant (9/24; 37%) ataxias, including patients with known ataxia. Patients with hereditary ataxia (including asymptomatic patients with known ataxia genotype) should be considered for screening for gluten sensitivity and gluten-free diet trials.

Hadjivassiliou  et al reported that patients with gluten ataxia have antibodies against Purkinje cells. Antigliadin antibodies cross-react with epitopes on Purkinje cells. Burk et al reported the symptoms of gluten ataxia: The clinical syndrome was dominated by progressive cerebellar ataxia with ataxia of stance and gait (100%), dysarthria (100%) and limb ataxia (97%). Oculomotor abnormalities were gaze-evoked nystagmus (66.7%), spontaneous nystagmus (33.3%), saccade slowing (25%) and upward gaze palsy (16.7%). Extracerebellar features also included deep sensory loss (58.3%), bladder dysfunction (33.3%) and reduced ankle reflexes (33.3%).

Luostarinen  et al suggested: It is well known that coeliac disease may be associated with various neurological manifestations. We have had a high index of suspicion of coeliac disease during recent years in our neurological clinic. As a result 10 (7%) out of 144 of our new coeliac patients were detected because of neurological symptoms. The most common neurological manifestations were neuropathy, memory impairment and cerebellar ataxia. In these patient groups screening for coeliac disease with serological antibody tests helps to find patients who may suffer from this disease.

Wills suggested A number of neurological syndromes have been described in association with coeliac disease. These include disorders of the central nervous system encompassing epilepsy, myoclonus, ataxia, internuclear opthalmoplegia, multifocal leukoencephalopathy and dementia. Most of these associated conditions show a poor response to gluten restriction. Peripheral neuropathies, of axonal and demyelinating types, have also been reported and may respond to elimination of gluten from the diet. The mechanism underlying these processes remains obscure but may be immunological or related to trace vitamin deficiencies. Controversially, it has also been claimed that occult coeliac disease accounts for a substantial proportion of patients with neurological dysfunction of unknown cause. Some authorities recommend that cryptogenic ataxias and neuropathies should be routinely screened for the presence of gluten-sensitivity but this remains contentious and has not been universally accepted.

Also see Celiac Disease

Bushara KO, Goebel SU, Shill H,  Goldfarb LG,  Hallett M  Gluten sensitivity in sporadic and hereditary cerebellar ataxia. Ann Neurol 2001 Apr;49(4):540-3

The humoral response in the pathogenesis of gluten ataxia. Hadjivassiliou M; Boscolo S; Davies-Jones GA; Grunewald RA; Not T; Sanders DS; Simpson JE; Tongiorgi E; Williamson CA; Woodroofe NM. Neurology 2002 Apr 23;58(8):1221-6

Luostarinen L, Pirttila T, Collin P. Coeliac disease presenting with neurological disorders. Eur Neurol 1999;42(3):132-5 Wills AJ.

The neurology and neuropathology of coeliac disease. Department of Neurology, University Hospital Nottingham, UK. Neuropathol Appl Neurobiol 2000 Dec;26(6):493-6

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  Human Nature
The Good Person
Pieces of the Puzzle
The Sound of Music
  Surviving Human Nature
  Language and Thinking
  I and Thou
  Emotions and Feelings
  Neuroscience Notes
  Human Brain
  Children and Family
  Intelligence and Learning
  Religion for 21st Century

Further reading:   Alpha Nutrition Program, Human Brain, Neuroscience Notes,  Intelligence and Learning -- Persona Digital books.

 

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