Brain Mind Center

Off-label use of atypical antipsychotics do more harm than good

There are growing concerns that more antipsychotic drugs are prescribed by more physicians without regard to lawful indications and obvious toxic effects.

"According to Alexander and colleagues in the February 2011 issue of Pharmacoepidemiology and Drug Safety, the estimated use of atypical antipsychotic medications for off-label indications, or without approval from the US Food and Drug Administration (FDA), has rapidly increased. Commonly prescribed atypical antipsychotic medications include quetiapine, risperidone, aripiprazole, olanzapine, asenapine, clozapine, iloperidone, paliperidone, and ziprasidone This systematic review and meta-analysis by Maher and colleagues assesses the efficacy and safety of atypical antipsychotic medication use for off-label indications of dementia, generalized anxiety disorder (GAD), and obsessive-compulsive disorder (OCD) in adults. (Deborah Brauser, Penny Murata. Few Benefits, Significant Adverse Effects Linked With Off-Label Atypical Use. Medscape Education Clinical Briefs 10/05/2011.) Off-label prescriptions are used to treat conditions such as dementia, anxiety, OCD, eating disorders, substance abuse, and posttraumatic stress disorder. Children and Senior are tow vulnerable populations that receive the most ill-advised prescriptions for antipsychotics.

Further Reading See

Avoid Antipsychotic Drugs Children
Avoid Antipsychotic Drugs Seniors

 Based on a meta- analysis of 231 large observational studies were assessed adverse events and included at least 1000 patients each.

JAMA. 2011; 306:1359-1369.


  • You are viewing the Brain Mind Center at Alpha Online. Understanding the human brain is essential to become a well-informed, modern citizen. Stephen Gislason MD, the author of the Human Brain, is a physician-writer who is good at making complex subjects more understandable. This is a book with important ideas, so be prepared to read and then keep the book as reference.
  • Alpha Online is a Division of Environmed Research, founded in 1984 at Vancouver, BC, Canada. Online Since 1995.
    Alpha Nutrition is a trademark and a division of Environmed Research Inc. 

     Download The Human Brain as an eBook


    All Alpha Education and Persona Digital books, eBooks and Starter packs are ordered online. Prices are listed in Canadian Dollars.
    US $ cost is lower depending on the daily dollar exchange rate. Physical shipments by the Post Officel are available to all destinations in the USA and Canada.
    We are located in Sechelt, close to Vancouver, British Columbia, Canada. eMail: alphaonline@nutramed.com

    Brain Rescue Starter Pack

    This starter pack includes the Alpha Nutrition Program, the Human Brain in Health and Disease and one 500 Gram jar of Alpha DMX. There are a host of clues that link the food supply to mysterious and threatening neurological diseases. We suggest that a prudent person suffering early brain-dysfunction symptoms would be wise to pursue vigorous, thorough diet revision at the earliest opportunity. Because some brain dysfunction compromises judgment learning and motivation, family members, friends and professional advisor often have to initiate diet revision and provide the right direction and support.

    Order Brain Rescue Starter Pack
  •  

    Order Persona Digital Books

    Click the Add to Cart buttons on the left to begin your order for printed books from Alpha Online (mail delivery to US and Canada).
    Download eBooks
    Click the Download button to order eBooks (PDF file) for download. Click book title (center column) to read topics from each book.

    Print Book" Read Topics Download
    Human Nature
    The Good Person
    Pieces of the Puzzle
    Sound of Music
    Surviving Human Nature
    Language & Thinking
    I and Thou
    Emotions & Feelings
    Neuroscience Notes
    Human Brain
    Children & Family
    Intelligence & Learning
    Religion 21st Century

Further reading: Neuroscience Notes, Intelligence and Learning, Language & Thinking

Persona Digital

Persona Digital Books is the publisher of The Human Brain, Neuroscience Notes, Intelligence & Learning and related books. Three books are available as print editions for mail delivery. All books are available as eBooks for download (PDF files).