Off-label use of atypical antipsychotics do more harm than good
There are growing concerns that more antipsychotic drugs are prescribed by
more physicians without regard to lawful indications and obvious toxic effects.
"According to Alexander and colleagues in the February 2011 issue of
Pharmacoepidemiology and Drug Safety, the estimated use of atypical
antipsychotic medications for off-label indications, or without approval from
the US Food and Drug Administration (FDA), has rapidly increased. Commonly
prescribed atypical antipsychotic medications include quetiapine, risperidone,
aripiprazole, olanzapine, asenapine, clozapine, iloperidone, paliperidone, and
ziprasidone This systematic review and meta-analysis by Maher and colleagues
assesses the efficacy and safety of atypical antipsychotic medication use for
off-label indications of dementia, generalized anxiety disorder (GAD), and
obsessive-compulsive disorder (OCD) in adults. (Deborah Brauser, Penny Murata.
Few Benefits, Significant Adverse Effects Linked With Off-Label Atypical Use.
Medscape Education Clinical Briefs 10/05/2011.) Off-label prescriptions are used
to treat conditions such as dementia, anxiety, OCD, eating disorders, substance
abuse, and posttraumatic stress disorder. Children and Senior are tow vulnerable
populations that receive the most ill-advised prescriptions for antipsychotics.
Further Reading See
Avoid Antipsychotic Drugs Children
Avoid Antipsychotic Drugs Seniors
Based on a meta- analysis of 231 large observational studies were assessed
adverse events and included at least 1000 patients each.
JAMA. 2011; 306:1359-1369.
- You are viewing the Brain Mind Center at Alpha Online.
Understanding the human brain is essential to become a well-informed, modern
citizen. Stephen Gislason MD, the author of
the Human Brain, is a physician-writer who is good at making complex subjects more
understandable. This is a book with important ideas, so be prepared to read
and then keep the book as reference.
- Alpha Online is a Division of Environmed Research, founded in 1984 at
Vancouver, BC, Canada. Online Since 1995. Alpha Nutrition is a trademark
and a division of Environmed Research Inc.
Download The Human Brain as an eBook
All Alpha Education and Persona Digital books, eBooks and Starter packs are ordered online.
Prices are listed in Canadian Dollars.
Brain Rescue Starter Pack
US $ cost is lower
depending on the daily dollar exchange rate. Physical shipments by the Post
Office are available to all destinations in the USA and Canada.
We are located in Sechelt, close to Vancouver, British Columbia, Canada. eMail:
This starter pack includes the Alpha Nutrition Program, the Human Brain in Health and Disease
and one 500 Gram jar of Alpha DMX. There are a host of clues that link the food supply to mysterious and threatening neurological
diseases. We suggest that a prudent person suffering early brain-dysfunction
symptoms would be wise to pursue vigorous, thorough diet revision at the
earliest opportunity. Because some brain dysfunction compromises judgment
learning and motivation, family members, friends and professional advisor often
have to initiate diet revision and provide the right direction and support.
Order Brain Rescue Starter Pack
Order Persona Digital Books
Click the Add to Cart buttons
on the left to begin your order for printed books from Alpha Online (mail delivery to US and
Download eBooks Click the Download button to order
eBooks (PDF file) for download. Click book title (center column) to read topics
from each book.
Further reading: Neuroscience Notes, Intelligence and
Learning, Language & Thinking
Persona Digital Books
is the publisher of The Human Brain, Neuroscience Notes, Intelligence & Learning
and related books. All books are available as eBooks for download (PDF files).