fruit Food Allergy

Some Topics

Eat Healthy Foods Be Happy

Immune Complexes

Von Pirquet first described serum sickness, the prototype of Immune Complex disease in 1925. Any food protein or peptide entering the circulation in sufficient quantity can produce symptom patterns resembling serum sickness. If antigens make it into the blood stream, they combine with circulating antibodies to produce circulating immune complexes (CICs).

Immune cells interact with CICs, triggering immune reactions with the release of symptom-producing mediators. Serum sickness manifests as a systemic illness, typically evolving over a period of 7-10 days. Manifestations include general malaise, fever, flushing, sweating, hives, swelling, bruising, aching in joints and muscles, progressing in the worst case to inflammatory disease in target organs with protein in the urine from kidney damage.

Food-enriched blood, coming from the gastrointestinal tract, goes through the liver where most immune-complexes are removed. If circulating complexes pass the liver filter, they may cause disturbances in many organs. The other path of absorption of molecules from the digestive tract is through lymphatic drainage. The lymph channels flow together to form the thoracic duct, a flimsy vessel which drains its contents into the subclavian vein. This pathway may direct antigenic molecules directly to the lungs where food antigens may excite asthmatic attacks, bronchitis, or more serious and enigmatic inflammatory lung diseases. The combination of antibody with antigen in the blood stream is a circulating immune complex (CIC).

CICs have the general form of: Antigen---Antibody

CICs may simply be removed from the circulation by macrophages or they may trigger a cascade of events which lead to multiple symptoms, and possibly tissue damage:

CICs ---> Mediator release ---> Symptoms

Mediators + Immune cells ---> Inflammation

CIC's activate complement, a circulating system of 25 proteins which interact to produce a variety of defensive molecular weapons. CIC's may not cause tissue injury unless access to tissue spaces is increased by leakiness of blood vessels, allowing influx of CIC's and cells. CIC's may not cause tissue injury unless vascular permeability is increased - allowing influx of CIC's and cells. The complement system modulates and amplifies the biological effects of CIC's.

The main function of the complement cascade is to assemble a drilling rig made of proteins attached to a cell wall and then to drill holes in the cell wall, allowing its contents to flow out. Complement intends to punch enough holes in a cell to kill it. If the attacked cell is a bacteria threatening to invade your private parts, your are happy with complement activity. If these drilling rigs are punching holes in your own cell walls, you will not be so happy. This sort of complement misadventure does occur. Like most immune attack systems, complement has go and stop mechanisms.

We can say that complement system modulates and amplifies the biological effects of CIC's. Once activated the complement cascades through a series of changes, producing powerful effects including anaphylaxis and blood cell damage. At the same time, certain complement products are essential to clear CIC's and to stop the cascade of cell damage. Individuals with deficiencies of complement proteins are at greater risk of developing immune-complex disease.

CIC's leave capillaries to trigger inflammatory events in target tissues. A classic model of complex-induced pathology is the Arthus reaction which appears 3-6 hours after antigen challenge and involves large insoluble (Type 3) complexes with complement (C3b) passing through vessel walls to excite inflammatory responses in target tissues. The Arthrus reaction can be prevented by depleting C3 with Cobra venom

Listen to an Introduction to Food Antigen Entry Into the Body

  • The Food Allergy Center is devoted to explaining a complicated subject. We offer rich resources online and encourage our readers to further pursue their interest by reading our books. This is an educational resource and order portal developed by Environmed Research Inc. Alpha Education books refer to the Alpha Nutrition Programa standard method of diet revision.

  • Managing Food Allergy

    Stephen Gislason MD explains how food allergy causes many diseases that can be corrected by using proper diet revision. Click download to order eBook

  • Download Free -- Food Allergy Abstracts
  • Hypoallergenic Nutrient Formulas Alpha Nutrition Formulas are gluten free and do not contain cows milk, soya, or egg ingredients. They do not contain food dyes or other additives. They are suitable for vegetarians.
  • Food Allergy Rescue A starter pack for all food allergy problems, anaphylaxis, hypersensitivity diseases, autoimmune diseases.
  • The Starter Pack Includes Alpha ENF, the Alpha Nutrition Program and the book, Food Allergy. Order Food Allergy Rescue Starter Pack

  • Order Alpha Education Books

    Alpha Education printed books, Alpha Nutrition formulas and Starter packs are ordered at Alpha Online.
    Click the Add to Cart buttons to begin your order for printed books, sent by the Post Office to all destinations in Canada and USA.
    Click the Download buttons to order eBooks.

Print Books Read Topics Download
Alpha Nutrition Program
Aching and Fatigue
Air and Breathing
Alpha Nutrition Cooking
Alcohol Problems
Gluten Problems
Managing Diabetes 2
Eating and Weight
Skin Disease
Feeding Children
Human Brain
Managing Food Allergy
Food & Digestive Disorders
Food Choices
Heart and Arterial Disease
Immunology Notes
Inflammatory Arthritis
Nutrition Notes

You are visiting the Food Allergy Center at Alpha Online, and educational resource and order portal developed by Alpha Nutrition.
Alpha Education books refer to the Alpha Nutrition Program a standard method of diet revision. The starter packs are sold at discounts to make it easier and more affordable for you to learn more and try our nutrient formulas. Alpha Education printed books, eBooks for download, Alpha Nutrition formulas and Starter packs are all ordered at Alpha Online. Physical shipments by the Post Office to destinations in Canada and USA.

Alpha Online

PayPal is a secure payment gateway that authorizes credit card payments. PayPal acts as a secure payment gateway for Visa, MasterCard, Discovery or AMEX credit cards. When your payment information is complete, you will receive an order confirmation email from PayPal and from Alpha Nutrition Online. We ship your order usually wthin two business day. Prices are listed in Canadian Dollars. US Costs are lower because of a favorable exchange rate. Please see Pay Pal Information

Alpha Nutrition ® is a registered trademark and a division of Environmed Research Inc., Sechelt, British Columbia, Canada. In business since 1984. Online since 1995. email Alpha Online Mail